肠道真菌研究进展

真菌菌群是肠道菌群的重要组成部分，在肠道微生态稳态的维持和宿主的免疫调节中发挥重要作用。肠道真菌失调通常和肠道疾病甚至肠道外疾病有关。本文就肠道真菌的定殖与组成、真菌菌群对肠道微生态的调控、菌群失调促进疾病的发展机制、基于肠道真菌的治疗策略和肠道真菌的鉴定分析方法等方面的进展进行了综述和展望，旨在系统认识肠道真菌调节宿主健康和促进疾病发生的机制，为相关疾病的诊断和治疗提供重要参考。

Research progress of gut mycobiota

As a vital component of the gut microbiota, mycobiota is involved in the maintenance of the intestinal microecosystem homeostasis and regulation of host immunity. Dysbiosis of the gut mycobiota has been well-documented to be associated with both intestinal diseases and extra-intestinal diseases. In this paper, the research progresses on gut mycobiota are summarized with regard to the composition and colonization, mechanisms associated with intestinal microecosystem, dysbiosis and disease development, and therapeutic approaches as well as methodologies of mycobiota analysis, aiming at providing comprehensive understanding of gut mycobiota in regulating host health and promoting disease occurrence, and delivering reference for clinical therapeutical applications.