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Furosemide-sensitive Na+-K+ cotransport and cellular metabolism in human erythrocytes |
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| Authors: | N C Adragna C M Perkins P K Lauf |
| Abstract: | Metabolic depletion of human red cells with 2-deoxy-D-glucose in the presence of EGTA decreased ATP to about 4% of the initial value and increased total ouabain- and furosemide-resistant Na+ and K+ effluxes by 20% and 100%, respectively, and furosemide-sensitive Na+ and K+ effluxes by 100% and 60%, respectively. When ATP was restored, all the components of Na+ and K+ fluxes measured returned to baseline levels suggesting a metabolic dependence. |
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