Possible molecular detent in the DNA structure at regulatory sequences |
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Authors: | P Lu S Cheung K Arndt |
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Institution: | Department of Chemistry, University of Pennsylvania, Philadelphia 19104. |
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Abstract: | A common feature that appears in a number of DNA sites where proteins interact is the sequence GTG/CAC. In the lac operator this sequence leads to a region with a higher imino proton exchange rate well below the optical melting temperature. It is suggested that this reflects a structural feature recognized by proteins that bind specific sites on the DNA molecule. |
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