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EspF of enteropathogenic Escherichia coli binds sorting nexin 9 |
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| Authors: | Marchès Oliver Batchelor Miranda Shaw Robert K Patel Amit Cummings Nicola Nagai Takeshi Sasakawa Chihiro Carlsson Sven R Lundmark Richard Cougoule Celine Caron Emmanuelle Knutton Stuart Connerton Ian Frankel Gad |
| Affiliation: | Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom. |
| Abstract: | EspF of enteropathogenic Escherichia coli targets mitochondria and subverts a number of cellular functions. EspF consists of six putative Src homology 3 (SH3) domain binding motifs. In this study we identified sorting nexin 9 (SNX9) as a host cell EspF binding partner protein, which binds EspF via its amino-terminal SH3 region. Coimmunoprecipitation and confocal microscopy showed specific EspF-SNX9 interaction and non-mitochondrial protein colocalization in infected epithelial cells. |
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