Nonsynonymous substitution rate (Ka) is a relatively consistent parameter for defining fast-evolving and slow-evolving protein-coding genes |
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| Authors: | Dapeng Wang Fei Liu Lei Wang Shi Huang Jun Yu |
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| Affiliation: | (1) CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, PR China;(2) Graduate University of Chinese Academy of Sciences, Beijing, 100049, PR China;(3) State Key Laboratory of Medical Genetics, Xiangya Medical School, Central South University, Changsha, Hunan, 410078, PR China |
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| Abstract: | Background Mammalian genome sequence data are being acquired in large quantities and at enormous speeds. We now have a tremendous opportunity to better understand which genes are the most variable or conserved, and what their particular functions and evolutionary dynamics are, through comparative genomics. |
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