CARd-3D: Carbon Distribution in 3D Structure Program for Globular Proteins |
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Authors: | Rajasekaran Ekambaram Akila Kannaiyan Vijayasarathy Marimuthu Vinobha Chinnaiah Swaminathan Senthil Renganathan Ananda Gopu Perumal |
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Abstract: | Spatial arrangement of carbon in protein structure is analyzed here. Particularly, the carbon fractions around individual atoms are
compared. It is hoped that it follows the principle of 31.45% carbon around individual atoms. The results reveal that globular
protein''s atoms follow this principle. A comparative study on monomer versus dimer reveal that carbon is better distributed in
dimeric form than in its monomeric form. Similar study on solid versus liquid structures reveals that the liquid (NMR) structure
has better carbon distribution over the corresponding solid (X-Ray) structure. The carbon fraction distributions in fiber and toxin
protein are compared. Fiber proteins follow the principle of carbon fraction distribution. At the same time it has another broad
spectrum of carbon distribution than in globular proteins. The toxin protein follows an abnormal carbon fraction distribution. The
carbon fraction distribution plays an important role in deciding the structure and shape of proteins. It is hoped to help in
understanding the protein folding and function. |
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Keywords: | crystal structure carbon distribution protein structure hydrophobic scale carbon fraction CARd3D |
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