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The in vitro screening of methylated 4-oxypiperidine compounds for inhibition of protein synthesis in a rabbit reticulocyte cell-free translation system |
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| Authors: | Dr Dimitrij A Kuznetsov Nikolay V Zavijalov Gennadij J Kelman Alexander V Govorkov |
| Institution: | (1) Laboratory of Toxicology, Moscow City Station for Sanitation and Epidemiology, Moscow, USSR;(2) Laboratory of Toxicology, Moscow City Station for Sanitation and Epidemiology, Grafski Pereulok 4/9, 129301 Moscow, USSR |
| Abstract: | A variety of methylated 4-oxypiperidine derivatives were tested for their ability to inhibit protein synthesis in vitro. A direct correlation was found between the extent of methylation of these compounds and their inhibitory activity in a rabbit reticulocyte lysate cell-free translation system.Abbreviation IC50 50% inhibitory concentration |
| Keywords: | antioxidant drug side effects nitroxyl-2 4-oxipiperidines protein synthesis translation system toxicity |
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