miR-26a Suppresses Tumor Growth and Metastasis by Targeting FGF9 in Gastric Cancer |
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| Authors: | Min Deng Hai-lin Tang Xi-hong Lu Mei-yuan Liu Xiao-min Lu Yi-xue Gu Ji-fang Liu Zhi-min He |
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| Institution: | 1. Cancer Hospital and Cancer Research Institute, Guangzhou Medical University, Guangzhou, China.; 2. Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.; 3. Cancer Research Institute, University of South China, Hengyang, China.; 4. Affiliated Nanhua Hospital, University of South China, Hengyang, China.; Institute of Molecular Medicine, Taiwan, |
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| Abstract: | The role of miR-26a in cancer cells seemed controversial in previous studies. Until now, the role of miR-26a in gastric cancer remains undefined. In this study, we found that miR-26a was strongly downregulated in gastric cancer (GC) tissues and cell lines, and its expression levels were associated with lymph node metastasis and clinical stage, as well as overall survival and replase-free survival of GC. We also found that ectopic expression of miR-26a inhibited GC cell proliferation and GC metastasis in vitro and in vivo. We further identified a novel mechanism of miR-26a to suppress GC growth and metastasis. FGF9 was proved to be a direct target of miR-26a, using luciferase assay and western blot. FGF9 overexpression in miR-26a-expressing cells could rescue invasion and growth defects of miR-26a. In addition, miR-26a expression inversely correlated with FGF9 protein levels in GC. Taken together, our data suggest that miR-26a functions as a tumor suppressor in GC development and progression, and holds promise as a prognostic biomarker and potential therapeutic target for GC. |
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