Biological evaluation of substituted quinolines |
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| Authors: | Franck Xavier Fournet Alain Prina Eric Mahieux Renaud Hocquemiller Reynald Figadère Bruno |
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| Institution: | Laboratoire de Pharmacognosie (associé au CNRS-BioCIS), Faculté de Pharmacie, Université de Paris-Sud, rue J.B. Clément, 92296 Chatenay-Malabry, France. |
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| Abstract: | Several quinolines were synthesized and evaluated in vitro against several parasites (Trypanosoma brucei, T. cruzi, Leishmania infantum, L. amazonensis, Plasmodium falciparum). Then, they were evaluated in vitro (at 10 microM), against HTLV-1 transformed cells. A few of them displayed interesting activities, comparable to the reference drugs. |
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