Preparation and Evaluation of Gelatin/Sodium Carboxymethyl Cellulose Polyelectrolyte Complex Microparticles for Controlled Delivery of Isoniazid |
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Authors: | Nirmala Devi Tarun Kumar Maji |
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Institution: | (1) Department of Chemical Sciences, Tezpur University, Napaam, 784028, India; |
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Abstract: | The ratio of gelatin to sodium carboxymethyl cellulose (SCMC) at which maximum yield was obtained was optimized. This optimized
ratio of gelatin to SCMC along with other parameters was used to prepare microparticles of different sizes. Vegetable oil
was used as emulsion medium. Effect of various factors like amount of surfactant, concentration of polymer on the formation,
and size of the microparticles was investigated. These microparticles were used as carrier for isoniazid. Among different
cross-linkers, glutaraldehyde was found to be the most effective cross-linker at the temperature and pH at which the reaction
was carried out. The loading efficiency and release behavior of loaded microparticles were found to be dependent on the amount
of cross-linker used, concentration of drug, and time of immersion. Maximum drug loading efficiency was observed at higher
immersion time. The release rate of isoniazid was more at higher pH compared to that of at lower pH. The sizes of the microparticles
were investigated by scanning electron microscope. In all the cases, the microparticles formed were found spherical in shape
except to those at low stirring speed where they were agglomerated. Fourier transform infrared study indicated the successful
incorporation of isoniazid into the microparticles. Differential scanning calorimetry study showed a molecular level dispersion
of isoniazid in the microparticles. X-ray diffraction study revealed the development of some crystallinity due to the encapsulation
of isoniazid. |
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