Synthesis of deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids |
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| Authors: | Ciuffreda Pierangela Casati Silvana Alessandrini Laura Terraneo Giancarlo Santaniello Enzo |
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| Institution: | Dipartimento di Scienze Precliniche LITA Vialba, Universitá degli Studi di Milano, Via G.B. Grassi, 74-20157, Milan, Italy. |
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| Abstract: | Deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids formation from cholesterol, were prepared from 2,2,3,4,4,6-2H(6)]-cholesterol and (20S)-7,7,21,21-2H(4)]-3beta-(tert-butyldimethylsilyl)oxy-20-methylpregna-5-en-21-ol, respectively. |
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| Keywords: | Deuterated isotopomers 7α-hydroxycholesterol (25R)-26-hydroxycholesterol Bile acids Cholesterol metabolism |
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