Circadian Variation of Cardiac Performance in Coronary Heart Disease |
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Authors: | A Wortmann K Bachmann |
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Institution: | Medical Clinic II, University Erlangen-Nuernberg, Krankenhausstr. 12, D-8520, Erlangen, FRG |
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Abstract: | To study the circadian variation of cardiac performance in patients with coronary heart disease, three exercise tests on a bicycle crgometer were performed during the active part of the day (10 a.m., 2 p.m. and 6 p.m.), recording ST-segment depression and pulmonary capillary wedge pressure. Ten male patients with angiographically documented coronary heart disease underwent bicycle ergometry during placebo and during nitrate therapy (placebo controlled, double-blind crossover 2 × 20 mg IS-5-MN and 1 × 120 mg ISDN sustained release). During placebo as well as during nitrate therapy there was a gradual decrease of cardiac performance during the day, documented by the increase in ST-depression and pulmonary capillary wedge pressure at equal work loads. High nitrate concns led to a significant reduction of both ST-depression and preload with a marked circadian-phase dependency of cardiovascular effects. |
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Keywords: | Coronary heart disease hemodynamics circadian rhythm interval therapy nitrates |
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