Genetic characterization of Toxoplasma gondii isolates from China |
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| Authors: | Peng Zhou Han Zhang Rui-Qing Lin De-Lin Zhang Hui-Qun Song Chunlei Su Xing-Quan Zhu |
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| Affiliation: | 1. State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China;2. Military Veterinary Institute, Academy of Military Medical Sciences, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, Jilin Province 130122, PR China;3. General Station for Surveillance of Wildlife Diseases & Wildlife Borne Diseases, State Forestry Administration (SFA), Shenyang 110034, PR China;1. Department of Microbiology, Kidwai Memorial Institute of Oncology, Dr. M. H. Marigowda Road, Bangalore 560029, India;2. Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar 563101, India;3. Department of Neuropathology, National Institute of Mental Health and Neurosciences, Dr. M. H. Marigowda Road, Bangalore 560029, India;4. Defence Food Research Laboratory, Defence Research & Development Organisation, Siddhartha Nagar, Mysore 570011, India;1. Department of Medical Parasitology and Mycology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;2. Department of Medical Parasitology and Mycology, Lorestan University of Medical Sciences, Khorramabad, Iran;3. Department of Biotechnology, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;5. Institute of Cancer, Tehran Medical Center of Children with Cancer, Tehran, Iran;1. Department of Parasitology, Ege University Medical School, Bornova/?zmir 35100, Turkey;2. Centre National de Référence (CNR) Toxoplasmose/Toxoplasma Biological Resource Center (BRC), Centre Hospitalier-Universitaire Dupuytren, Limoges 87042, France;3. INSERM UMR 1094, Neuroépidémiologie Tropicale, Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, Université de Limoges, Limoges 87025, France;4. Department of Molecular Biology, Ege University Faculty of Sciences, Bornova/?zmir 35100, Turkey;5. Ankara University Medical School, Department of Parasitology, Ankara 06100, Turkey |
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| Abstract: | ![]()
Toxoplasma gondii infections are prevalent in humans and animals worldwide. In North America and Europe, T. gondii is highly clonal, consisting of three distinct lineages (Types I, II and III), whereas in South America, T. gondii is highly diverse with a few lineages expanded in the population. However, there is limited data on the diversity of T. gondii in Asia. Here we report the genetic characterization of T. gondii isolates from different hosts and geographical locations in China using the multilocus PCR–RFLP. A total of 17 T. gondii isolates from humans (3 strains), sheep (1 strain), pigs (5 strains) and cats (8 strains) were typed at 10 genetic markers including 9 nuclear loci SAG1, SAG2, SAG3, BTUB, GRA6, L358, PK1, c22-8, c29-2 and an apicoplast locus Apico. Four genotypes were revealed, including three previously reported and one new genotype. Three isolates belong to the clonal Type I lineage, one isolate belongs to the clonal Type II lineage, and the rest 13 isolates are grouped into two genotypes. This is the first report of genetic typing of T. gondii isolates from different hosts and geographical locations in China using a number of genetic markers, which has implications for the studies of population genetic structures of T. gondii, as well as for the prevention and control of T. gondii infections in humans and animals in China. |
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