Inheritance of mitochondrial aldehyde dehydrogenase: genotyping in Chinese,Japanese and South Korean families reveals dominance of the mutant allele |
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| Authors: | Surjit Singh Gernot Fritze Bingliang Fang Shoji Harada Yong K Paik Rolf Eckey Dharam P Agarwal H Werner Goedde |
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| Institution: | (1) Institut für Humangenetik der Universität, Butenfeld 32, D-2000 Hamburg 54, Germany;(2) Department of Medical Genetics, Institute of Basic Medical Sciences, Beijing, China;(3) Department of Community Medicine, University of Tsukuba, Tsukuba, Japan;(4) Department of Genetics, Hanyang University School of Medicine, 133-791 Seoul, South Korea |
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| Abstract: | Summary Genotyping of mitochondrial aldehyde dehydrogenase (ALDH I) was performed in enzymatically amplified DNA of 20 Chinese, Japanese and South Korean families (85 individuals) and in 113 unrelated persons by employing allele-specific oligonucleotide probes and dot blot hybridization. Genotyping individuals with phenotypic deficiency of ALDH I activity always showed the presence of at least one mutant allele. The data are compatible with a model assuming dominant inheritance of the mutant allele, which we have previously suggested on the basis of a population study. |
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