|
|||||
|
|
Antimycobacterial drugs that inhibit mycolic acid synthesis |
|
| Authors: | Kuni Takayama Leslie A Davidson |
| Institution: | K. Takayama and L. A. Davidson are at the Tuberculosis Research Laboratory, William S. Middleton Memorial Veterans Medical Center, and the Institute for Enzyme Research, University of Wisconsin, Madison, WI 53706, U.S.A. |
| Abstract: | Antimycobacterial drugs such as isoniazid; ethionamide and thiocarlide are inhibitors of mycolic acid synthesis in Mycobacterium tuberculosis. Isoniazid in particular appears to block the formation of a Δ5−C24:1 fatty acid which could be a precursor of mycolic acids. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |