|
|||||
|
|
Biosynthesis of modified peptidoglycan precursors by vancomycin-resistant Enterococcus faecium |
|
| Authors: | NE Allen JN Hobbs Jr JM Richardson RM Riggin |
| Institution: | Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285. |
| Abstract: | In the presence of bacitracin, vancomycin-resistant Enterococcus faecium (vanA phenotype) accumulate UDP-N-acetylmuramyl(UDP-Mur-NAc)-tetrapeptide and a UDP-MurNAc-depsipentapeptide containing lactate substituted for the carboxy-terminal-D-alanine residue. In an in vitro peptidoglycan polymerization assay, the modified precursors function and confer resistance to vancomycin. |
| Keywords: | Vancomycin resistance Peptidoglycan precursor UDP-MurNAc-pentapeptide UDP-MurNAc-tetrapeptide UDP-MurNAc-depsipentapeptide Enterococcus faecium |