Flavonoids as receptor tyrosine kinase FLT3 inhibitors |
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| Authors: | Young-Won Chin Jae Yang Kong Sun-Young Han |
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| Institution: | 1. College of Pharmacy, Dongguk University-Seoul, Goyang, Gyeonggi-do 410-820, South Korea;2. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongnam 660-701, South Korea |
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| Abstract: | The Fms-like tyrosine kinase 3 (FLT3), a receptor tyrosine kinase, is involved in the proliferation, differentiation and apoptosis of hematopoietic cells. FLT3 is highly overexpressed in acute myeloid leukemia (AML) of the majority of patients. Screening for flavonoids including flavones, flavanones, flavonols, and flavanonols disclosed that luteolin was potent FLT3 enzyme inhibitor. Furthermore, luteolin suppressed cell proliferation in MV4;11 cells with constitutively activated FLT3. |
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