Synthesis and antitumor-evaluation of 1,3-selenazole-containing 1,3,4-thiadiazole derivatives |
| |
| Authors: | Hai-Chuan Zhao Yan-Ping Shi Yu-Ming Liu Cai-Wen Li Li-Na Xuan Peng Wang Kai Zhang Bao-Quan Chen |
| |
| Institution: | Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China |
| |
| Abstract: | A series of novel 1,3-selenazole-containing 1,3,4-thiadiazole derivatives bearing Schiff base moieties were synthesized and evaluated for their in vitro antiproliferative activities against human breast cancer cell MCF-7 and mouse lymphocyte leukemia cell L1210 by CCK-8 assay. The majority of the compounds showed better activity against MCF-7 cell, compared with lead compound PCS. In particular, compound 6c was the most potent compound with IC50 value of 4.02 μM. |
| |
| Keywords: | 1 3-Selenazole 1 3 4-Thiadiazole derivatives Schiff base Antitumor agents |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
