Psammaplysin F: A unique inhibitor of bacterial chromosomal partitioning |
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| Authors: | Deborah M. Ramsey Md. Amirul Islam Lynne Turnbull Rohan A. Davis Cynthia B. Whitchurch Shelli R. McAlpine |
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| Affiliation: | 1. Department of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia;2. The ithree institute,University of Technology, Sydney, Ultimo, NSW 2007, Australia;3. Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia |
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| Abstract: | ![]()
Described is the antibiotic activity of a marine natural product. Psammaplysin F (1) inhibited the growth of four Gram-positive strains by >80% at 50 μM, and the amine at position C-20 is responsible for the observed antibacterial activity. When tested against two strains of methicillin resistant Staphylococcus aureus (MRSA), the minimum inhibitory concentrations (MICs) for psammaplysin F (40–80 μM) were similar to the structurally-related alkaloid psammaplysin H (2). Psammaplysin F (1) increased membrane permeability by two to four-fold compared to psammaplysin H (2) or control-treated bacteria, respectively. Unlike psammaplysin H (2), we show that psammaplysin F (1) inhibits equal partitioning of DNA into each daughter cell, suggesting that this natural product is a unique prokaryotic cell division inhibitor. |
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| Keywords: | Natural products Antibiotics DNA Amine Cell division |
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