Thermal stability of oligodeoxynucleotide duplexes containing l-deoxynucleotide at termini |
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| Authors: | Hidehito Urata Shuji Ogawa Shun-ichi Wada |
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| Affiliation: | Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan |
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| Abstract: | ![]()
The effects of substituting l-deoxynucleotide for d-deoxynucleotide at duplex termini were evaluated and the terminal substitutions were found to show much less effects on duplex destabilization and to show a similar tendency in base pairing selectivity, compared with internal chiral substitutions. |
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| Keywords: | DNA duplex Enantiomer Heterochiral DNA Terminal base pair Thermal stability |
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