Synthesis and biological evaluation of novel alkyl amide functionalized trifluoromethyl substituted pyrazolo[3,4-b]pyridine derivatives as potential anticancer agents |
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Authors: | K Chavva S Pillalamarri V Banda S Gautham J Gaddamedi P Yedla CG Kumar N Banda |
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Institution: | 1. Fluoroorganic Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India;2. Chemical Biology Laboratory, Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India |
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Abstract: | A series of novel alkyl amide functionalized trifluoromethyl substituted pyrazolo3,4-b]pyridine derivatives 5, 6 and 7 were prepared starting from 6-phenyl-4-(trifluoromethyl)-1H-pyrazolo3,4-b]pyridin-3-amine 3 via selective N-alkylation, followed by reaction with different primary aliphatic amines, cyclic secondary amines or l-amino acids under different set of conditions. All the synthesized compounds 5, 6 and 7 were screened for anticancer activity against four cancer cell lines such as A549—Lung cancer (CCL-185), MCF7—Breast cancer (HTB-22), DU145—Prostate cancer (HTB-81) and HeLa—Cervical cancer (CCL-2). The compounds 5i and 6e are found to have promising bioactivity at micro molar concentration. |
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Keywords: | Alkylation Primary aliphatic amines Cyclic secondary amines Anticancer activity |
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