Ionotropic Receptors (IRs): Chemosensory ionotropic glutamate receptors in Drosophila and beyond |
| |
| Authors: | Raphael Rytz Vincent Croset Richard Benton |
| |
| Affiliation: | 1. Education Ministry Key Laboratory of Integrated Management of Crop Diseases and Pests, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China;2. Suqian Entry-exit Inspection and Quarantine Bureau, Suqian, Jiangsu, China;1. Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans-Knöll-Straße 8, D-07745 Jena, Germany;2. Department of Entomology, Max Planck Institute for Chemical Ecology, Hans-Knöll-Straße 8, D-07745 Jena, Germany;3. Department of Biology, Barnard College, Columbia University, 3009 Broadway, New York, NY 10027, USA;4. Department of Microbiology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, NY 10029, USA;5. Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur Boston, MA 02115, USA;1. Department of Biology, University of Wisconsin Oshkosh, Oshkosh, WI, United States;2. Department of Biology, Lund University, Lund, Sweden;1. State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China;2. College of Life Sciences, University of Chinese Academy of Sciences, Beijing, PR China |
| |
| Abstract: | ![]()
Ionotropic Receptors (IRs) are a recently characterized family of olfactory receptors in the fruit fly, Drosophila melanogaster. IRs are not related to insect Odorant Receptors (ORs), but rather have evolved from ionotropic glutamate receptors (iGluRs), a conserved family of synaptic ligand-gated ion channels. Here, we review the expression and function of IRs in Drosophila, highlighting similarities and differences with iGluRs. We also briefly describe the organization of the neuronal circuits in which IRs function, comparing and contrasting them with the sensory pathways expressing ORs. Finally, we summarize the bioinformatic identification and initial characterization of IRs in other species, which imply an evolutionarily conserved role for these receptors in chemosensation in insects and other protostomes. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
