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An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: Emerging ‘Novel Psychoactive Drugs’ |
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| Authors: | Warunya Arunotayanun Jeffrey W Dalley Xi-Ping Huang Vincent Setola Ric Treble Leslie Iversen Bryan L Roth Simon Gibbons |
| Institution: | 1. Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK;2. Behavioral and Clinical Neuroscience Institute, Department of Psychology, University of Cambridge, Cambridge CB2 3EB, UK;3. Department of Pharmacology, Program in Neuroscience and Division of Chemical Biology and Medicinal Chemistry, and National Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina, Chapel Hill Medical School, Chapel Hill, NC 27514, USA;4. LGC Forensics, Queens Road, Teddington, London TW11 0LY, UK;5. Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK |
| Abstract: | Novel Psychoactive Drugs (NPD) can be sold without restriction and are often synthetic analogues of controlled drugs. The tryptamines are an important class of NPD as they bind to the various serotonin (5-HT) receptor subtypes and cause psychosis and hallucinations that can lead to injury or death through misadventure. Here we report on the structure elucidation and receptor binding profiles of two widely marketed tryptamine-derived NPDs, namely alpha-methyl-tryptamine and 5-methoxy-N,N-diallyl-tryptamine. |
| Keywords: | Tryptamines Alpha-methyl-tryptamine LSD Novel Psychoactive Drugs (NPD) |
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