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Inhibition of HIV-1 replication by a tricyclic coumarin GUT-70 in acutely and chronically infected cells |
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| Authors: | Eriko Kudo Manabu Taura Kouki Matsuda Masako Shimamoto Ryusho Kariya Hiroki Goto Shinichiro Hattori Shinya Kimura Seiji Okada |
| Institution: | 1. Division of Hematopoiesis, Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan;2. Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga 849-8501, Japan |
| Abstract: | The anti-HIV-1 activity of GUT-70, a natural product derived from the stem bark of Chlophyllum brasiliense, was evaluated. GUT-70 inhibited HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB. Our results strengthen the idea that NF-κB pathway is one of the potential targets to control HIV-1 replication and that GUT-70 could serve as a lead compound to develop novel therapeutic agents against HIV-1 infection. |
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