Anti-neuroinflammatory diarylheptanoids from the rhizomes of Dioscorea nipponica |
| |
| Authors: | Kyeong Wan Woo Eunjung Moon Oh Wook Kwon Sung Ok Lee Sun Yeou Kim Sang Zin Choi Mi Won Son Kang Ro Lee |
| |
| Affiliation: | 1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-ku, Suwon, Gyeonggi-do 440-746, Republic of Korea;2. Gachon Institute of Pharmaceutical Science, Gachon University, #191 Hambakmoe-ro, Yeonsu-gu, Incheon 406-799, Republic of Korea;3. College of Pharmacy, Gachon University, #191 Hambakmoe-ro, Yeonsu-gu, Incheon 406-799, Republic of Korea;4. Graduate School of East-West Medical Science, Kyung Hee University Global Campus, #1732 Deogyeong-daero, Giheung-gu, Yongin, Gyeonggi-do 446-701, Republic of Korea;5. Dong-A Pharm Institute, Kiheung, Yongin, Gyeonggi-do 449-905, Republic of Korea |
| |
| Abstract: | ![]()
In a continuing search for bioactive constituents from Dioscoreaceae medicinal plants, two new cyclic diarylheptanoids, diosniponol A (1) and B (2), together with 10 known compounds (3–12) were isolated from the rhizomes of Dioscorea nipponica. The structures of these new compounds were determined by spectroscopic analyses, including extensive two-dimensional nuclear magnetic resonance, high-resolution mass spectrometry, and optical rotation. All isolated compounds 1–12 were evaluated for their effects on nitric oxide (NO) production in murine microglia cell line BV-2. Compounds 8 and 11 showed potent inhibitory activities on NO production (IC50 13.36 and 14.36 μM, respectively) without cell toxicity in lipopolysaccharide-activated BV-2 cells. |
| |
| Keywords: | Dioscoreaceae Diarylheptanoids Nitric oxide Anti-neuroinflammation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
