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Participation of capsaicin-sensitive neurons in the cardiovascular effects of neurotensin in guinea pigs |
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| Authors: | H l ne Bachelard Serge St-Pierre and Francis Rioux |
| Institution: | a Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada J1H 5N4 b INRS-Santé, Université du Québec, Montréal, QC, Canada H1N 3M5 |
| Abstract: | Intravenous (IV) infusions of neurotensin (NT) in anesthetized guinea pigs elicited dose-dependent pressor effects and tachycardia. Both effects were significantly reduced or abolished in guinea pigs given a chronic treatment with the neurotoxin capsaicin. In guinea pig isolated atria NT evoked a positive inotropic and chronotropic effect. Both effects were completely abolished in atria derived from capsaicin-treated guinea pigs. The positive inotropic and chronotropic effects of NT in guinea pig atria were mimicked by capsaicin and calcitonin gene-related peptide (CGRP). These results were interpreted as an indication that NT produces its cardiovascular effects in guinea pigs by activating capsaicin-sensitive sensory neurons. |
| Keywords: | Neurotensin Capsaicin Substance P Calcitonin gene-related peptide Blood pressure Heart rate Tachycardia Bradycardia Primary afferents |
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