Effects of the non-competitive NMDA receptor antagonist ketamine on morphine-induced place preference in mice |
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Authors: | Suzuki T Kato H Aoki T Tsuda M Narita M Misawa M |
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Institution: | Department of Toxicology, School of Pharmacy, Hoshi University, Tokyo, Japan. suzuki@hoshi.ac.jp |
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Abstract: | The effects of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, on morphine-induced place preference were examined in mice. Morphine (1-5 mg/kg, s.c.) produced a dose-related place preference in mice. Ketamine alone (3, 10 mg/kg, i.p.), like dizocilpine alone (0.2 mg/ kg, i.p.), also produced a preference for the drug-associated place. Pretreatment with ketamine (10 mg/ kg, i.p.) or dizocilpine (0.1 and 0.2 mg/kg, i.p) suppressed the place preference produced by morphine in a dose-dependent manner. These findings provide the first demonstration that ketamine alone produces a place preference using the conditioned place preference (CPP) paradigm, but that mice treated with ketamine combined with morphine show neither a morphine- nor a ketamine-induced place preference. |
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