Amino acid transport in the renal proximal tubule |
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Authors: | T Gonska J R Hirsch E Schlatter |
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Institution: | Medizinische Poliklinik, Experimentelle Nephrologie, Westf?lische Wilhelms-Universit?t, Münster, Federal Republic of Germany, DE
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Abstract: | Summary. In the kidney the proximal tubule is responsible for the uptake of amino acids. This occurs via a variety of functionally
and structurally different amino acid transporters located in the luminal and basolateral membrane. Some of these transporters
show an ion-dependence (e.g. Na+, Cl− and K+) or use an H+-gradient to drive transport. Only a few amino acid transporters have been cloned or functionally characterized in detail
so far and their structure is known, while little is known about a majority of amino acid transporters. Only few attempts
have been untertaken looking at the regulation of amino acid transport. We summarized more recent information on amino acid
transport in the renal proximal tubule emphasizing functional and regulatory aspects.
Received August 8, 1999; Accepted April 20, 2000 |
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Keywords: | : Amino acids – Kidney – IHKE-1-cells – LLC-PK1-cells – Regulation – DOG – PKC |
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