Structure-activity relationships for non-steroidal inhibitors of aromatase |
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| Authors: | L Banting H J Smith M James G Jones W Nazareth P J Nicholls M J Hewlins M G Rowlands |
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| Affiliation: | Welsh School of Pharmacy, Cardiff, U.K. |
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| Abstract: | A model is described for the binding of non-steroidal inhibitors of aromatase to the enzyme with interaction of a ligand with the Fe3+-haem of the cytochrome. The model suggests that the inhibitors utilise a common binding site with ring A of the steroidal substrates. |
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