戊型肝炎病毒细胞培养模型的研究进展 |
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引用本文: | 张玉林[综述],王玲[审校],庄辉[审校].戊型肝炎病毒细胞培养模型的研究进展[J].微生物学免疫学进展,2013(5):42-46. |
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作者姓名: | 张玉林[综述] 王玲[审校] 庄辉[审校] |
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作者单位: | 北京大学医学部病原生物学系和感染病中心,北京100191 |
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基金项目: | 国家自然科学基金资助项目(81271827);高等学校博士学科点专项科研基金课题(20120001110098) |
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摘 要: | 戊型肝炎病毒( HEV)体外细胞培养模型的建立有助于阐明HEV的感染、复制及其致病机理,有利于新型抗病毒药物和疫苗的研发与评估。近年来国内外对HEV细胞培养模型的报道很多,但所用细胞系、感染方法及病毒的复制效果等不尽相同。因此,对近年来HEV细胞培养模型的研究进展进行了综述。
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关 键 词: | 戊型肝炎病毒 细胞培养模型 病毒复制 |
Progress on cell culture models for hepatitis E virus |
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Institution: | ZHANG Yu-lin, WANG Ling, ZHUANG Hui ( Department of Microbiology and Infectious Disease Center, Peking University Health Science Center, Beijing 100191, China) |
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Abstract: | The development of cell culture models for hepatitis E virus ( HEV) in vitro can help to elucidate the mecha-nisms for HEV infection , replication and pathogenesis , thus promoting the development and evaluation of new antivirus agents and vaccines.In recent years, many studies on HEV cell culture models have been reported , however, these studies showed differences in the cell lines , infecting methods and viral replication effects .This review summarizes the progress on HEV cell culture models . |
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Keywords: | Hepatitis E virus Cell culture model Virus replication |
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