梅毒螺旋体膜蛋白研究进展

梅毒螺旋体苍白亚种（ Tp）引起的梅毒是一种严重危害人类健康的慢性性传播性疾病，其发病具有多阶段、进行性的特点。由于Tp尚不能体外培养，抗原获取困难，其致病机制研究尚不清楚。随着Tp全基因序列的解析，重组Tp膜蛋白的成功表达及蛋白功能结构日益明确，为Tp发病机制的研究及疫苗的研制奠定了良好的基础。对于Tp主要外膜蛋白的结构、功能研究进展进行了综述。

Advances in treponema pallidum membrane protein.

Syphilis is a serious sexually transmitted disease , caused by treponema pallidum subsp.Pallidum （ T.palli-dum） , with the disease characteristics of multistage and progressive .As T.pallidum cannot be cultured in vitro , it is really hard to acquire its antigen and thus its pathogenic mechanism is still unclear .With the publication of T.pallidum gene se-quence , the successful expression of membrane protein and more understanding of the function and structure of T.pallidum protein, it has laid a good foundation for the research of T.pallidum pathogenesis , as well as the development of vaccine . This review attempts to give an overview about the structure and function of T.pallidum membrane protein .