Deletion polymorphism in a Drosophila melanogaster heat shock gene |
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| Authors: | Karl Sirotkin Nancy Bartley William L. Perry III Douglas Briggs Ed H. Grell Christine Morganelli |
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| Affiliation: | (1) Department of Microbiology, University of Tennessce, 37996-0845 Knoxville, TN, USA;(2) Biology Department, Dartmouth College, 03755 Hanover, NH, USA;(3) Biology Division, Oak Ridge National Laboratory, 37830 Oak Ridge, TN, USA;(4) Graduate Program in Cellular, Molecular and Developmental Biology, University of Tennessee, 37996 Knoxville, TN, USA;(5) Department of Biology, Indiana University, 47405 Bloomington, IN, USA;(6) Present address: Department of Physiology, University of California, San Francisco, CA, USA |
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| Abstract: | We have continued the transcriptional analysis of the region of cytological locus 67B that contains the four small heat shock genes and other genes. Transcription from one of the heat shock genes in the region, hsp 26, takes place during high temperature treatment and at certain developmental stages, without heat shock, in several tissues, such as imaginal discs and adult ovaries. Observations of unexpected products after nuclease protection experiments provided the first indication of what genomic blot experiments showed to be small deletions. The alleles containing the deletion are expressed at the same level as the wild type allele. The deletion shortens the protein product, implying that it is in the coding region. Furthermore, flies homozygous for one of the deletion alleles are viable. |
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