Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk |
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Authors: | Pfizenmaier K Jung H Kurrle R Röllinghoff M Wagner H |
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Institution: | Institut für Medizinische Mikrobiologie der Johannes-Gutenberg-Universit?t, Augustusplatz, D-6500 Mainz, Federal Republic of Germany. |
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Abstract: | Herpes-simplex-virus (HSV) specific, H-2k-restricted, immune cytotoxic T lymphocytes also lyse noninfected H-2d target cells. Genetic mapping studies revealed that HSV-specific Dk-restricted CTL cross-react with allogeneic targets expressing Dd alloantigens. Cold target inhibition experiments indicate that only a minority of HSV-specific CTL mediate cross-reactive cytolysis. The data give an example of where the phenomenon of H-2-restricted versus nonrestricted responsiveness is not due to distinct subsets of T cells but solely depends on the antigenic determinants recognized. |
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