Analysis of hybrids between an H-2+, TL? lymphoma and an H-2+, TL+ lymphoma and its H-2?, TL? variant subline |
| |
Authors: | Robert Hyman Valerie Stallings |
| |
Institution: | (1) Department of Cancer Biology, The Salk Institute for Biological Studies, Post Office Box 1809, 92112 San Diego, California |
| |
Abstract: | Hybrids between an H-2+, TL+ lymphoma and an H-2+, TL– lymphoma were studied for their expression of H-2 and TL antigens. The H-2 antigens of both parents were expressed, the TL specificity of the TL+ parent was retained, and the TL specificity characteristic of the mouse strain from which the TL– lymphoma was derived was not expressed. There was no evidence that the genome of either parent altered the expression of the TL antigens coded for by the genome of the opposite parent. Hybrids between the H-2+, TL– lymphoma and an H-2–, TL– variant line derived from the H-2+, TL+ cell line expressed both theK- andD-regioncoded H-2 antigens and the TL specificity characteristic of the parental cell line from which the variant cell was derived. This result is consistent with the defect in the variant cell's being the result of a mutation affecting a gene coding for a positive element necessary for expression of both TL and the serologically detectable H-2 antigens on the cell surface. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|