Increase of sialyltransferase activity in the serum and liver of inflamed rates |
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Authors: | Ian H Frasher Timothy Coolbear Sailen Mookerjea |
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Institution: | Department of Biochemistry, Memorial University of Newfoundland, St. John''s, Newfoundland A1B 3X9 Canada |
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Abstract: | Induction of inflammation by turpentine injection caused 1.5–2-fold increase of both sialy- and galactosyltransferase activity in liver homogenates. The effect was apparent after 12 h turpentine treatment. Serum sialytransferase activity started to increase in the inflamed rats after 18 h, reaching a maximum of 4-fold at 48 h. In contrast, galactosyltransferase activity in serum showed no significant increase. The coordinated and temporal increase of sialytransferase activity in liver and serum suggest involvement of a specific mechanism for the preferential release of this enzyme into serum. |
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Keywords: | Inflammation Sialyltransferase Turpentine (Rat) Mes 4-morpholineethanseulphonic acid |
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