| HIV-1载体的研发沿革 |
| |
| 引用本文： | 张帆,张敬之.HIV-1载体的研发沿革[J].生命科学,2010(3):296-301. |
| |
| 作者姓名： | 张帆 张敬之 |
| |
| 作者单位： | 上海交通大学医学遗传研究所;上海交通大学附属儿童医院; |
| |
| 基金项目： | 国家高技术研究发展计划(“863”项目)(2007AA021206) |
| |
| 摘 要： | 自从科学家于1983年发现了人类免疫性缺陷病毒1(human immunodeficiency virus1,HIV-1)以来,随着对它的研究不断深入,其表达载体的开发也有了长足的进步。与其他逆转录病毒载体相比,如莫罗尼小鼠白血病病毒(murine leukemiavirus,MLV)载体和泡沫病毒(foamyvirus,FV)载体等,HIV-1载体具有诸多独特的优点,因而有着更广泛的应用于临床基因治疗的前景。该文对HIV-1载体的研发过程及其优缺点进行综述。
|
| 关 键 词： | 人类免疫性缺陷病毒1 慢病毒载体 HIV-1载体 SIN载体 |
The advances of HIV-1 vector research |
| |
| ZHANG Fan,ZHANG Jing-zhi.The advances of HIV-1 vector research[J].Chinese Bulletin of Life Sciences,2010(3):296-301. |
| |
| Authors: | ZHANG Fan ZHANG Jing-zhi |
| |
| Institution: | ZHANG Fan1,2,ZHANG Jing-zhi1,2(1 Shanghai Institute of Medical Genetics,Shanghai Jiao Tong University,Shanghai 200040,China,2 Shanghai Children\'s Hospital affiliated to Shanghai Jiao Tong University,China) |
| |
| Abstract: | Since the first discovery of human immunodeficiency virus 1(HIV-1) in 1983,scientists have gained a lot of insights on HIV-1.At the meantime,the research on its vector has been made quite big achievements.In contrast to other retroviral vectors,such as murine leukemia virus(MLV) vector,or foamy virus(FV) vector,HIV-1 vector holds a few unique advantages,which is more suitable for the usage in gene therapy.In this review,the research advances in HIV-1 vector with its features have been extensively discussed. |
| |
| Keywords: | human immunodeficiency virus 1 lentiviral vector HIV-1 vector SIN vector |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
