In vitro protoscolicidal effects of hypertonic glucose on protoscolices of hydatid cyst |
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Authors: | Hosseini Seyed Vahid Ghanbarzadeh Kurosh Barzin Jahra Sadjjadi Seyed Mahmoud Tanideh Nader Mehrabani Davood |
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Institution: | Department of Surgery, Gastroenterohepatology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. hoseiniv@sums.ac.ir |
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Abstract: | To evaluate the protoscolicidal effects of various concentrations of hypertonic glucose, live protoscolices of sheep were exposed to 10%, 15%, 25% and 50% glucose solutions. Cetrimide (0.5%), silver nitrate (0.5%) and hypertonic saline (20%) were used as positive controls, while physiological saline was used as a negative control. After 1, 2 and 5 min, the protoscolicidal effects were determined by 1% eosin. A 25% glucose solution had no significant protoscolicidal effect. However, a 50% glucose solution revealed higher protoscolicidal effect than 0.5% silver nitrate but weaker effect than 0.5% cetrimide; the effect was comparable with that of 20% hypertonic saline. The results showed that hypertonic glucose solution is highly effective in killing protoscolices of Echinococcus granulosus in vitro. |
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Keywords: | Echinococcus granulosus hydatid cyst protoscolices protoscolicidal agents hypertonic glucose solution |
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