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Few alterations in clinical pathology and histopathology observed in a CYP2C18&;19 humanized mice model |
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| Authors: | Susanne Löfgren Stina Ekman Ylva Terelius Ronny Fransson-Steen |
| Institution: | 1.Safety Assessment Sweden,AstraZeneca R&D S?dert?lje,S?dert?lje,Sweden;2.Department of Biomedical Sciences and Veterinary Public Health,Division of Pathology, Pharmacology & Toxicology,Uppsala,Sweden;3.Medivir AB,Huddinge,Sweden |
| Abstract: | BackgroundThis study was performed to characterize a gene-addition transgenic mouse containing a BAC (bacterial artificial chromosome) clone spanning the human CYP2C18&19 genes (tg-CYP2C18&19). |
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