| 综述: 血管衰老及其机制 |
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| 引用本文： | 姜平,黎健.综述: 血管衰老及其机制[J].生物化学与生物物理进展,2014,41(3):295-304. |
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| 作者姓名： | 姜平 黎健 |
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| 作者单位： | 卫生部北京医院/卫生部北京老年医学研究所，北京 100730,卫生部北京医院/卫生部北京老年医学研究所，北京 100730 |
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| 基金项目： | 国家自然科学基金(31371160)和卫生部卫生行业科研专项项目(201302008)资助 |
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| 摘 要： | 血管老化是一个古老而又年轻的课题.本文综述了血管衰老的主要结构特征、功能改变及其机制的新近研究进展,重点就血管基质变化、内皮细胞衰老/功能失调、内皮祖细胞衰竭以及细胞间通讯等方面进行了阐述.
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| 关 键 词： | 血管衰老 内皮细胞 内皮祖细胞 微粒 外泌体 microRNA |
| 收稿时间： | 2013/12/19 0:00:00 |
| 修稿时间： | 2013/12/19 0:00:00 |
Review: Vascular Aging and The Corresponding Mechanisms |
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| JIANG Ping and LI Jian.Review: Vascular Aging and The Corresponding Mechanisms[J].Progress In Biochemistry and Biophysics,2014,41(3):295-304. |
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| Authors: | JIANG Ping and LI Jian |
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| Institution: | The Key Laboratory of Geriatrics, Beijing Hospital and The Key Laboratory of Geriatrics, Beijing Hospital |
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| Abstract: | Vascular aging has attracted curiosity and excited imagination throughout the history of humankind. This review focuses on structural and functional changes that occur in the vasculature during aging, as well as the novel founding mechanisms, with special emphasis on extracellular matrix alterations, endothelial progenitor cells endothelial exhaustion, senescence/dysfunction, and altered intercellular communication. |
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| Keywords: | vascular aging endothelial cell endothelial progenitor cells (EPCs) microparticle exosome microRNA |
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