Inhibition of mouse brain synaptosomal gamma-aminobutyric acid transport by pyridoxal 5'-phosphate |
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Authors: | G Tunnicliff |
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Institution: | Department of Microbial Biochemistry, Glaxo Group Research Ltd., Greenford Road, Greenford, Middlesex, UB6 OHE UK. |
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Abstract: | Crude lysates from a strain of enterotoxigenic have been shown to catalyse the incorporation of 32P] from adenylate-32P] NAD+ into an 11,000 dalton protein in rat liver membranes. 32P] incorporation paralleled adenylate cyclase activation and the results suggest that the mechanism of action of the heat-labile enterotoxin may involve ADP-ribosylation of an intracellular acceptor protein. |
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