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Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection |
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| Authors: | Allen Todd M Jing Peicheng Calore Briana Horton Helen O'Connor David H Hanke Tomas Piekarczyk Marian Ruddersdorf Richard Mothé Bianca R Emerson Carol Wilson Nancy Lifson Jeffrey D Belyakov Igor M Berzofsky Jay A Wang Chenxi Allison David B Montefiori David C Desrosiers Ronald C Wolinsky Steven Kunstman Kevin J Altman John D Sette Alessandro McMichael Andrew J Watkins David I |
| Institution: | Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, WI 53715, USA. tallen2@partners.org |
| Abstract: | Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication. |
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