In vivo administration of Fab' fragments of anti-L3T4 (GK1.5) antibody inhibits the T helper cell function of murine lymph node cells |
| |
| Authors: | N E Street K Uyemura V M Sanders J W Uhr E S Vitetta |
| |
| Institution: | Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235. |
| |
| Abstract: | The effect of intravenous injection of Fab' fragments of anti-L3T4 antibody (GK1.5 monoclonal antibody) into mice was studied. This treatment depleted L3T4+ cells from the popliteal lymph nodes of keyhole-limpet hemocyanin-primed mice. The T cells that remained were unable to provide help to antigen-specific B cells in vitro. The results obtained using Fab' fragments were comparable with those using intact anti-L3T4 antibody and demonstrate that either form of GK1.5 is a potentially useful immunosuppressive agent in mice. |
| |
| Keywords: | |
|
