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Circadian Rhythm in Pineal Methionine S-Adenosyltransferase
Authors:Ras B. Guchhait  rew A. Monjan
Affiliation:Department of Epidemiology, The Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland, U.S.A.
Abstract:
Abstract: The circadian rhythm of methionine S -adenosyltransferase, which catalyzes the formation of S -adenosylmethionine, a cosubstrate for melatonin in the pineal gland, follows the pattern of hydroxyindole- O -methyltransferase. Around the middle of the dark period, methionine S -adenosyltransferase and hydroxyindole- O -methyltransferase appear to be elevated by 2.5- and 1.5-fold, respectively, and tend to fall back during the light period.
Keywords:Circadian rhythm    Hydroxyindole-O-methyltransferase    Melatonin    Methionine S-adenosyltransferase    S-Adenosylmethionine
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