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Inhibitors of BACE for treating Alzheimer's disease: a fragment-based drug discovery story
Institution:1. Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065, United States;2. Merck Research Laboratories, 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States;1. School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China;2. School of Life Sciences, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China;3. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China;4. Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, 110840, People’s Republic of China;1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China;2. Food and Drug Administration of Beijing, Yanqing District, Beijing, 102100, China;3. Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, China;1. College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, 473061, China;2. Nanyang Normal University Hospital, Nanyang Normal University, Nanyang, 473061, China;3. West China Hospital, Sichuan University, Chengdu, 610041, China;4. Henan Key Laboratory of Insect Biology in Funiu Mountain, China-UK-NYNU-RRes Joint Laboratory of Insect Biology, Nanyang Normal University, Nanyang 473061, China;5. Institute of Traditional Chinese Medicine Pharmacology and Toxicology, Sichuan Academy of Chinese Medicine Sciences, Chengdu, 610041, China
Abstract:
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