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Metal-based methods for protein inactivation
Affiliation:1. INRS – Centre Armand-Frappier, Laboratoire d''études moléculaires et pharmacologiques des peptides, 531 boul. des Prairies, Ville de Laval, QC H7V 1B7, Canada;2. INRS – Centre Armand-Frappier, Groupe de Recherche en Ingénierie des Peptides et en Pharmacothérapie (GRIPP), 531 boul. des Prairies, Ville de Laval, QC H7V 1B7, Canada;3. INSERM-U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, IRIB, Université de Rouen, 76821 Mont-Saint-Aignan, France;4. Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada
Abstract:
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  • Highlights► The irreversible inactivation of protein targets by metal complexes is described. ► The article summaries catalysts that hydrolyze or oxidize proteins. ► Cyclen-based catalysts that selectively hydrolyze peptides and proteins are described. ► Catalysts that generate reactive oxygen species are important for protein inactivation. ► Metal-based oxidants are potent and selective agents for protein inactivation.
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