Polyribonucleotide-anthraquinone interactions: in vitro antiviral activity studies. |
| |
Authors: | J M Jamison K Krabill D G Flowers C C Tsai |
| |
Institution: | Department of Chemistry, Kent State University, Ohio 44242. |
| |
Abstract: | Twelve anthraquinones (AQ) were evaluated for their ability to potentiate the antiviral activity of poly r(A-U) using a human foreskin fibroblast-vesicular stomatitis virus bioassay in which the AQ was combined with 0.2 mM poly r(A-U) to produce an AQ/ribonucleotide ratio of 1/4. Poly r(A-U) and the AQ alone were not effective antiviral agents. Five of the twelve AQs tested, mitoxantrone, adriamycin, ametantrone, carminic acid and daunomycin, enhanced the antiviral activity of poly r(A-U) 9- to 13-fold. The interferon-inducing activity of the five active AQ/poly r(A-U) combinations was equal to the sum of the interferon-inducing activities of their constituents. These five AQs appear to potentiate the antiviral activity of poly r(A-U) without superinduction of interferon. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|