Revisiting the Stimulus-Secretion Coupling in the Adrenal Medulla: Role of Gap Junction-Mediated Intercellular Communication |
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Authors: | Claude Colomer Michel G Desarménien Nathalie C Guérineau |
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Institution: | (1) Institute of Functional Genomics, Montpellier, France;(2) CNRS UMR5203, Montpellier, France;(3) INSERM U661, Montpellier, France;(4) University of Montpellier, Montpellier, France |
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Abstract: | The current view of stimulation-secretion coupling in adrenal neuroendocrine chromaffin cells holds that catecholamines are
released upon transsynaptic sympathetic stimulation mediated by acetylcholine released from the splanchnic nerve terminals.
However, this traditional vertical scheme would merit to be revisited in the light of recent data. Although electrical discharges
invading the splanchnic nerve endings are the major physiological stimulus to trigger catecholamine release in vivo, growing
evidence indicates that intercellular chromaffin cell communication mediated by gap junctions represents an additional route
by which biological signals (electrical activity, changes in intracellular Ca2+ concentration,…) propagate between adjacent cells and trigger subsequent catecholamine exocytosis. Accordingly, it has been
proposed that gap junctional communication efficiently helps synapses to lead chromaffin cell function and, in particular,
hormone secretion. The experimental clues supporting this hypothesis are presented and discussed with regards to both interaction
with the excitatory cholinergic synaptic transmission and physiopathology of the adrenal medulla. |
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Keywords: | Gap junctions Adrenal medulla Innervation Chromaffin cells Cholinergic synaptic transmission Catecholamine release Stimulus-secretion coupling Development Stress Physiopathology |
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