Antibody responses to Cryptosporidium antigen in HIV-positive patients in the Republic of Korea |
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Authors: | Guk Sang-Mee Chai Jong-Yil Shin Yung-Oh Seo Min |
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Institution: | Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, Seoul, Korea. |
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Abstract: | The diagnosis of cryptosporidiosis has been carried out using coprologic techniques in the Republic of Korea. However, antibody responses to Cryptosporidium have rarely been studied. Serum antibodies from HIV-positive/oocyst-positive Korean patients recognized significantly 31 and 27 kDa antigens, and HIV-negative/oocyst-positive individuals clearly reacted to 15/17 kDa antigens. Compared with oocyst-positive cases, 18.7% and 75.8% of sera from HIV-positive patients reacted to 31 and 27 kDa antigens. Only 11.1% of HIV-negative individuals reacted to 15/17 kDa. Based on these findings, serum antibody responses were different between HIV-positive and HIV-negative individuals infected with Cryptosporidium, and it is suggested that HIV-positive patients are more frequently exposed to C. parvum compared to HIV-negative individuals. |
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