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O-Heterocyclic Embeurekols from Embellisia eureka,an Endophyte of Cladanthus arabicus |
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| Authors: | Weaam Ebrahim Amal H. Aly Attila Mándi Victor Wray El Mokhtar Essassi Tarik Ouchbani Rachid Bouhfid Wenhan Lin Peter Proksch Tibor Kurtán Abdessamad Debbab |
| Affiliation: | 1. Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, 35516 Mansoura, Egypt;2. Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany;3. Department of Organic Chemistry, University of Debrecen, POB 20, 4010 Debrecen, Hungary;4. Helmholtz Centre for Infection Research, Inhoffenstraße 7, D-38124 Braunschweig, Germany;5. Laboratoire de Chimie Organique Hétérocyclique, Faculté des Sciences, Université Mohammed-V Agdal, Avenue Ibn Batouta, BP. 1014 Rabat, Morocco Moroccan Foundation Advanced Science, Innovation and Research (MAScIR), Institute of Nanomaterials and Nanotechnology (INANOTECH), ENSET, Av. de l'Armée Royale, Madinat El Irfane, 10100 Rabat, Morocco;6. Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany Laboratoire de Chimie Organique Hétérocyclique, Faculté des Sciences, Université Mohammed-V Agdal, Avenue Ibn Batouta, BP. 1014 Rabat, Morocco;7. Moroccan Foundation Advanced Science, Innovation and Research (MAScIR), Institute of Nanomaterials and Nanotechnology (INANOTECH), ENSET, Av. de l'Armée Royale, Madinat El Irfane, 10100 Rabat, Morocco;8. National Research Laboratories of Natural and Biomimetic Drugs, Peking University, Health Science Center, 100083 Beijing, People's Republic of China |
| Abstract: | Three new polyketides (-)-1 , (+)-1 , and 2 ) were isolated from the EtOAc extract of the fungus Embellisia eureka, an endophyte of the Moroccan plant Cladanthus arabicus (Asteraceae). The structures of these new compounds were determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of (-)-1 , (+)-1 , and 2 were determined by TDDFT ECD calculations of solution conformers, online HPLC-ECD analysis, and the modified Mosher method. Chirality 25:250–256, 2013. © 2013 Wiley Periodicals, Inc. |
| Keywords: | Cladanthus endophyte Embellisia structure elucidation TDDFT ECD calculation |