Distribution of various nickel compounds in rat organs after oral administration |
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Authors: | Shigeko Ishimatsu Toshihiro Kawamoto Koji Matsuno Yasushi Kodama |
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Institution: | (1) Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishi-ku, 807 Kitakyushu, Japan |
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Abstract: | In this study, eight kinds of nickel (Ni) compounds were orally administered to Wistar male rats and the distribution of each
compound was investigated 24 h after the administration. The Ni compounds used in this experiment were nickel metal Ni−M],
nickel oxide (green) NiO(G)], nickel oxide (black) NiO(B)], nickel subsulfide Ni3S2], nickel sulfide NiS], nickel sulfate NiSO4], nickel chloride NiCl2], and nickel nitrate Ni(NO3)2]. The solubilities of the nickel compounds in saline solution were in the following order; Ni(NO3)2>NiCl2>NiSO4]≫NiS>Ni3S2]>NiO(B)>Ni−M>NiO(G)]. The Ni level in the visceral organs was higher in the rats given soluble Ni compounds; Ni(NO3)2, NiCl2, NiSO4, than that in the rats receiving other compounds. In the rats to which soluble Ni compounds were administered, 80–90% of
the recovered Ni amounts in the examined organs was detected in the kidneys. On the other hand, the Ni concentration in organs
administered scarcely soluble Ni compounds; NiO(B), NiO(G), and Ni−M were very low. The estimated absorbed fraction of each
Ni compounds was increased with the increase of the solubility. These results suggest that the kinetic behavior of Ni compounds
administered orally is closely related with the solubility of Ni compounds, and that the solubility of Ni compounds is one
of the important factors for determining the health effect of Ni compounds. |
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Keywords: | Ni compounds oral administration chemical formula of Ni compounds solubility Ni distribution in organs rat |
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